FATIGUE OF HUMAN RED BLOOD CELLS IN HEALTH AND DISEASE

Human red blood cells (RBCs) are responsible for delivering oxygen to the organs and tissues from the lungs. During its lifespan, an RBC needs to squeeze through the smallest openings (i.e., smallest capillaries and splenic interendothelial slits) in the human body many times, and go through repeated hypoxia-normoxia cycles. Using our established microfluidic platform, we have shown that both mechanical fatigue and hypoxia-normoxia fatigue (through hypoxia-normoxia cycles) may cause significant mechanical degradation of RBCs. The results are compared between healthy RBCs and sickle cell disease (SCD) RBCs, and provide underlying mechanisms for a much shorter lifespan of SCD RBCs.
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THERMO-MECHANICAL FATIGUE CRACK GROWTH INVESTIGATION FOR CAST AUSTENITIC STAINLESS STEEL

This paper describes a complete experimental program and its numerical counterpart to investigate and predict failure analysis (crack initiation and propagation) of a cast 1.4837 heat-resistant austenitic stainless steel commonly used for automotive turbochargers. Fatigue crack growth analysis is the focus of this paper considering both isothermal and anisothermal loading for both experimental and finite element analysis. On this basis fatigue crack growth rate model is derived accounting for complex interaction of large levels of plasticity and subsequent crack closure.
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CRYSTAL PLASTICITY MODELING OF FATIGUE CRACK GROWTH IN STAINLESS STEEL

Predicting the crack behavior under monotonic and cyclic loading is essential for an accurate assessment of the reliability of engineering structures. This work is concerned with the deformation fields in crack tip grains and their effects on fatigue crack growth rates under cyclic loading. We develop a cyclic crystal plasticity finite element (CPFE) model to characterize the mechanical behavior of 316L stainless steel. The deformation fields in crystal grains near crack tips under monotonic and cyclic loading are studied for two crack tip grain orientations using CPFE simulations. The CPFE results under monotonic loading are consistent with previous theoretical and experimental results. The CPFE results under cyclic loading match those from cyclic J2 plasticity finite element (JPFE) simulations. Based on the accumulated plastic work, cyclic CPFE simulations predict the fatigue crack growth rate as a function of stress intensity factor. The predicted Paris law exponent is consistent with the experimental value. This work demonstrates a new CPFE approach to predict both the deformation field and fatigue crack growth rate in metal alloys. This approach may be further generalized to investigate the time dependent crack growth that can be strongly influenced by the crystallographic effects of crack tip grains.
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DEVELOPMENT OF THE NOVEL MIXED MODE ULTRASONIC FATIGUE TEST SYSTEM BASED ON FREQUENCY RESPONSE FUNCTION AND DYNAMIC MODAL ANALYSIS

In case it is important to characterizze the ultra-high fatigue behaviors of a metal, ultrasonic fatigue tests can be considered due to high test frequences. Moreover, it is quite important to understand the ultra-high fatigue life of metals under multi-axial stress status practically. This research demonstrates how to develop a novel mixed mode ultrasonic fatigue test system based on Frequency Response Function and Dynamics Modal Analysis, and the compatibility of the fatigue system is validated by experiments.
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MULTIAXIAL FATIGUE BEHAVIOR OF SLM TI6AL4V ALLOY: X-RAY COMPUTED Μ-TOMOGRAPHY ANALYSIS [Keynote]

Crack formation and propagation phenomena in selective laser melting (SLM) Ti-6Al-4V alloy samples were analyzed under combined axial and torsional fatigue loads. In fact, SLM defects lead to a lower fatigue strength and a larger fatigue life variation with respect to to conventionally manufactured parts. Internal defects were captured by X-ray computed μ-tomography (μ-CT) and their evolution was monitored by interrupted fatigue tests. Critical defects were analyzed by the strain intensity factor (SIF) using two differ- ent models based on the Murakami’s method: a modified Smith-Watson and Topper (MSWT) criterion and a virtual strain energy (VSE) criterion. The trend of the crack growth rate was analyzed by the effective defect area at different number of fatigue cycles. The μ-CT data were also used to build finite element models (FEM) of cracked samples to analyze the whole stress-strain distribution in the near crack tip region.
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BIAXIAL LOADING IMPACT ON FATIGUE CRACK PROPAGATION IN METALLIC MATERIALS

Multiaxial fatigue testing generates curved cracks that are extremely difficult to characterize using standard
compliance based and potential drop-based methods. Therefore, an automated online system was
developed to monitor the crack tips positions in plate cruciform specimens. The system periodically
evaluates the deformation fields at small areas around the crack tips by performing digital image correlation
(DIC) on images obtained by a moving camera triggered at desired phases of the loading cycle. The
displacement field obtained by DIC is fitted by a simple model that specifies the crack propagation direction
and enables it to iteratively find new crack tip positions. Moreover, the model is capable of computing the
crack opening displacements near the crack tip and thus characterizes the local loading. This approach
enables fully automated multiaxial testing with controlled crack length and crack tip loading. The method
was successfully tested on an AA5754 aluminium alloy sheet..Multiaxial fatigue testing generates curved cracks that are extremely difficult to characterize using standard
compliance based and potential drop-based methods. Therefore, an automated online system was
developed to monitor the crack tips positions in plate cruciform specimens. The system periodically
evaluates the deformation fields at small areas around the crack tips by performing digital
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BACK TO BASICS FOR THE FATIGUE CRACK GROWTH RATE IN METALLIC ALLOYS

The field of fracture mechanics started with Griffith’s energy concept for brittle fracture in 1920. In 1963, Paris et al. used a fracture mechanics’ parameter to introduce an equation for the fatigue crack growth rate in ductile materials and this equation is now commonly known as the ‘Paris law’. However, the Paris law and the semi-empirical models that followed ever since do not fully account for the main intrinsic and extrinsic properties involved with fatigue crack growth in metallic alloys. In contrast, here we introduce a dimensionally correct fatigue crack growth rate equation that is based on the original crack driving force as introduced by Griffith and the presence of plasticity in a metal to withstand crack propagation.
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FATIGUE AND DWELL-FATIGUE BEHAVIOR OF A FORGED TI-6AL-4V ALLOY INVESTIGATED BY HIGH-RESOLUTION DIGITAL IMAGE CORRELATION

The present work is dedicated to a comparative analysis of strain accumulation and damage initiation in a forged Ti-6Al-4V alloy subjected to either fatigue or dwell-fatigue condition. To this end, high-resolution digital image correlation analyses were carried out on fatigue specimens interrupted at different number of cycles to clarify the grain-scale strain activity and correlate it with local micro-mechanical features and crack initiation sites.
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A DIRECT APPROACH TO FATIGUE CRACK GROWTH UNDER LARGE SCALE PLASTICITY (PRESENTATION IN HONOR OF JODEAN MORROW, UNIVERSITY OF ILLINOIS)

The major challenge in the mechanics of elastic-plastic fatigue crack growth (FCG) is to find a physically based driving force to correlate the crack growth rates under stress-controlled and strain-controlled conditions. Specifically, a parameter capable of providing a single-valued correlation of crack growth rate, regardless of applied fatigue stress/strain values, is needed. Approaches of the past used either cyclic strain (strain intensity factor) or nonlinear fracture mechanics based (cyclic J-integral, ∆J) parameter, to correlate fatigue crack growth. The latter, however, requires experimental load-deflection curve after every crack length increment and geometry correction factors, which are complex. In the present work, it is shown that a new and physically based approach, based on the cumulative change in the cyclic strain energy of the net-section, is used to successfully correlate fatigue crack growth in a variety of loading elastic-plastic loading situations. The change in the cyclic strain energy is determined analytically from tensile elastic-plastic behavior of material and from the relative sizes of cracked and uncracked sections in the crack plane. Remarkably, excellent correlations of fatigue crack growth data in a variety of specimen geometries and stress/strain levels have been found for both stress- and strain-controlled fatigue conditions.
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EFFECT OF DYNAMIC EMBRITTLEMENT ON FATIGUE CRACK PROPAGATION MECHANISM AND CRACK GROWTH RATE IN IN718 [Keynote]

IN718 is a commonly used nickel-base alloy for high temperature applications, e.g., in gas and steam turbines. At elevated temperatures, this and other superalloys are prone to the failure mechanism “dynamic embrittlement”. In order to reveal the mechanism of dynamic embrittlement, high-temperature fatigue crack propagation tests were carried out at 650°C applying various dwell times and testing frequencies. Most of the tests were performed in laboratory air, but some experiments were run in vacuum as well, in order to eliminate environmental effects and, hence, to define the reference fatigue crack propagation behavior. Based on the results obtained, a model was developed for the range of test parameters, where intergranular and transgranular areas exist side by side in the fracture surface. This model provides a quantitative mechanismen-related description of the effect of dynamic embrittlement on fatigue crack propagation rate.
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