NONINVASIVE DIAGNOSIS OF BLOOD VESSEL DISEASES RELATED TO VISCOELASTIC DETERIORATION OF BLOOD VESSEL WALL [Plenary Lecture]

Studies of the strength deterioration of blood vessel were conducted under in vitro pulsatile pressure conditions. Furthermore, as an application of this results to the non destructive inspection, an algorithm of noninvasive diagnosing blood vessel diseases was established by detecting the acceleration response of blood vessel wall under pulsatile conditions, which estimates viscoelasticity of blood vessel wall characterized by our proposed parameter of I*. This method and theory were shown to be used to predict coronary artery disease by the clinical research. Furthermore, this method was applied to detect non-invasively the existence of aneurysm based on chaos theory. In this research, by dividing frequencies that compose the frequency of the pulsatile velocity of blood vessel wall into low and high frequency regions and conducting attractor analyses of the trajectory of pulsatile blood vessel wall, the possibility of accurate selective detection of blood vessel diseases such as mechanical deterioration of blood vessel wall ( low frequency region) and morphological change of blood vessel wall that are aneurysm (high frequency region) was indicated. In this lecture, close link of mechanical behavior of blood vessel wall with clinical disease of blood vessel is conducted.
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